Abstract
Some new macrocycles such as acyclic and cyclic nanomeric thia-aza and aza-crown systems 3, 4, and 6-9 have been synthesized through oxidation and/or Ru-complexation of compounds 2 and/or 5 in different conditions. The structures of the new products were deduced from their elemental analysis, spectral data, and physical study. The obtained systems were evaluated as potential inhibitors of cyclindependent kinases 2 for tumor cells; interestingly, compounds 4-7 showed excellent activity. The IC50 values of compounds 7a-b, 6b, 4, 6a, 5b, and 5a were in order 4.0, 4.2, 4.5, 4.8, 5.0, and 5.5 mu M, respectively, in comparison with the olomoucine drug used.
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