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Synthesis of Some New Substituted 2-Mercaptoquinazoline Analogs as Potential Antimicrobial Agents
Journal article   Peer reviewed

Synthesis of Some New Substituted 2-Mercaptoquinazoline Analogs as Potential Antimicrobial Agents

Adel S. El-Azab
Phosphorus, sulfur, and silicon and the related elements, Vol.182(2), pp.333-348
01/02/2007
DOI: https://doi.org/10.1080/10426500600919207

Abstract

1,3,4-oxadiazoles 1,3,4-thiadiazoles 2-quinazolines antimicrobial agent condensations Synthetic chemistry
A new series of substituted 2-mercapto-3-(4-chlorophenyl)-6-iodo-3H-quinazolin-4-ones was prepared and screened for antimicrobial activity. Compounds 11, 13, 17, and 18 showed a remarkably broad spectrum of antimicrobial activity and could be useful as templates for further development through modification or derivatization to design more potent antimicrobial agents. A detailed synthesis of new 2-mercaptoquinazolinones and their antimicrobial screening are reported.

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