Abstract
In search for new antiinflammatory agents, some new substituted thiobarbituric acids (2) and their bis-fused or fused thiopyrimidinylpyrimidinone (7, 8) have been derived from sulfathiazole and dimethylmalonate with CS2. structures of the synthesized compounds were established by spectroscopic (FT-IR, H-1 NMR, C-13 NMR, Mass) and elemental analyses. The antiinflammatory activity of these compounds was tested against carrageen-induced oedema with the reference of standard drug phenyl butazone. The results showed that compounds 2 and 3 are better antiinflammatory agents as compared to standard drug phenyl butazone.