Abstract
Reaction of N-(5-acetyl-4-methylthiazol-2-yl)-2-cyanoacetamide 2 with hydrazonoyl chlorides (3a,b) yielded the corresponding aminopyrazole derivatives (5a,b), respectively. Reaction of 2 with alpha,beta-benzylidenemalononitrile derivatives 8a,b and 13a,b afforded the corresponding pyridine derivatives 12a,b and 17a,b, respectively. Treatment of 2 with phenylisothiocyanate in dimethylformamide/KOH followed by the addition of ethyl chloroacetate and the appropriate hydrazonoyl chlorides 3a,b and 27 gave the corresponding 1,3-thiazole 21 and 1,2,4-thiadiazole derivatives 24a,b and 30, respectively. The newly synthesized compounds were confirmed from their elemental analyses and spectral data.