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Synthesis of a Novel Series of 2,3-Disubstituted Quinazolin-4(3H)-ones as a Product of a Nucleophilic Attack at C(2) of the Corresponding 4H-3,1-Benzoxazin-4-one
Journal article   Peer reviewed

Synthesis of a Novel Series of 2,3-Disubstituted Quinazolin-4(3H)-ones as a Product of a Nucleophilic Attack at C(2) of the Corresponding 4H-3,1-Benzoxazin-4-one

Mahr A. El-Hashash and Yaser A. El-Badry
Helvetica chimica acta, Vol.94(3), pp.389-396
01/03/2011
DOI: https://doi.org/10.1002/hlca.201000230

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A new series of 2,3-disubstituted quinazolin-4(3H)-one derivatives was synthesized by nucleophilic attack at C(2) of the corresponding key starting material 2-propyl-4H-3,1-benzoxazin-4-one (Scheme 2). The reaction proceeded via amidinium salt formation (Scheme 3) rather than via an N-acylanthranilimide. The structure of the prepared compounds were elucidated by physical and spectral data like FT-IR, (1)H-NMR, and mass spectroscopy.

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