Abstract
Aspirin, one of nonsteroidal anti-inflammatory analgesic drugs, was labeled with
125
I with a labeling yield of 85.5% under the following conditions: pH 9, 100 mg of the substrate, 50 µg of Chloramine-T, 5–15 min, room temperature. The radiochemical yield of
125
I-aspirin was determined by paper chromatography and electrophoresis, and the radiochemical purity was determined by HPLC.
125
I-aspirin was stable for at least 3 h. Biodistribution of
125
I-aspirin in normal and tumor-bearing mice was studied. The uptake of
125
I-aspirin in tumor sites makes it promising as a new radiopharmaceutical for tumor imaging.