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Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties
Journal article   Peer reviewed

Synthesis of a novel enantiopure imidazo-isoxazole derivatives and in silico prediction of ADME/pharmacokinetics properties

Mejdi Snoussi, Ameni Ghabi, Majdi Abid, Abdullah Althunayyan, Azdah M. Alassaf, Fahad Alminderej, Abuzar E. A. E. Albadri, Wael A. El-Sayed, Adel Kadri and Kaiss Aouadi
Egyptian journal of chemistry, Vol.66(1), pp.353-360
01/01/2023
DOI: https://doi.org/10.21608/EJCHEM.2022.126231.5597

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
Some novel enantiopure 3-carboxylic isoxazolidine derivatives were synthesized by stereocontrol 1,3-dipolar cycloaddition (1,3-DC) between nitrone derived (-)-menthone with alkenes derived from phenol and benzyl alcohol. Furthermore, the synthesized molecules were optimized for their drug-likeness and pharmacokinetics parameters by using in silico methods.

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