Abstract
6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via (HNMR)-N-1, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 +/- 0.20 mu M) and n-propyl gallate (IC50 = 30.30 +/- 0.40 mu M) were used as standard in cytotoxic and antioxidant activities, respectively. Compound 1 (IC50 = 3.30 +/- 0.90 mu M), 2 (IC50 = 2.70 +/- 0.25 mu M), 3 (IC50 = 2.70 +/- 0.25 mu M), 10 (IC50 = 2.70 +/- 1.10 mu M), 11 (IC50 = 1.00 +/- 1.20 mu M), and 17 (IC50 = 3.75 +/- 0.90 mu M) showed excellent while 21 (IC50 = 7.50 +/- 0.60 mu M) and 28 (IC50 = 7.50 +/- 0.66 mu M) showed moderate anti cancer activity. Furthermore, compound 10 (IC50 = 17.50 +/- 0.85 mu M), 11 (IC50 = 24.20 +/- 0.55 mu M), 12 (IC50 = 21.10 +/- 1.58 mu M), 13 (IC50 = 14.60 +/- 0.32 mu M), 14 (IC50 = 29.20 +/- 0.75 mu M) and 15 (IC50 = 9.26 +/- 0.15 mu M) showed better antioxidant activity than the standard n-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential.