Abstract
Novel chiral N-carbamate-protected gamma-amino-beta-ketones 3a-c and the known N-carbamate-protected nitroketone 3d were prepared from the corresponding 1-(N-protected alpha-aminoacyl) benzotriazoles 1 by reaction with nucleophiles 2a-d in the presence of bases under mild conditions. Similarly achiral and chiral N-protected gamma-amino-beta-ketoesters 3e-1 were prepared by reaction with acetoacetates in the presence of sodium hydride.