Sign in
Back
Synthesis of an amino moiety in trovafloxacin by using an in-expensive amidine base, N,N-diethylacetamidine
Journal article   Peer reviewed

Synthesis of an amino moiety in trovafloxacin by using an in-expensive amidine base, N,N-diethylacetamidine

G. Madhusudhan, V. Balraju, T. Rajesh, B. Venkata Narayana and R. Naveen Reddy
Indian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry, Vol.48(4), pp.569-573
01/04/2009

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
The simple and in-expensive amidine base, N,N-diethylacetamidine has been prepared and utilized in the construction of bicyclic hetero compound, 4 and employed for further reduction of amidic carbonyl groups of 4 by using NaBH4/I-2-THF condition which is an efficient and commercially viable method to prepare 5 towards the synthesis of amino moiety 1, in Trovafloxacin 2 an antibacterial agent.

Metrics

1 Record Views

Details