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Synthesis of an antitumor active endoperoxide from 11-keto-beta-boswellic acid
Journal article   Peer reviewed

Synthesis of an antitumor active endoperoxide from 11-keto-beta-boswellic acid

Rene Csuk, Anja Niesen-Barthel, Alexander Barthel, Ralph Kluge and Dieter Stroehl
European journal of medicinal chemistry, Vol.45(9), pp.3840-3843
01/09/2010
DOI: https://doi.org/10.1016/j.ejmech.2010.05.036
PMID: 20538386

Abstract

Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
An endoperoxide was synthesized starting from 11-keto-beta-boswellic acid and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The compound induces apoptosis and shows an average IC(50) value of 0.4-4.5 mu M. (C) 2010 Elsevier Masson SAS. All rights reserved.

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