Abstract
Four analogues of ochratoxin A (OTA) differing for the aminoacidic moiety were synthesised using ochratoxin alpha (OT alpha) as the starting material. The condensation reaction between protected amino acids and OT alpha, carried out in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC center dot HCl) and N-hydroxybenzotriazole (HOBt) as coupling agents, followed by deprotection and PTLC purification afforded OTA alanine, leucine, serine and tryptophane analogues in satisfactory yields (33-47%, based on OT alpha).