Abstract
A new series of
N
-(6-chlorobenzothiazol-2-yl)-2-substituted-acetamides (
3a
–
h
) and
N
-(6-chlorobenzothiazol-2-yl)-2-(substituted-benzylidene)hydrazinecarbothioamides (
5a
–
h
) were synthesized and characterized by IR,
1
H NMR, mass and elemental analysis. In vivo anticonvulsant and acute toxicity screening of all the synthesized compounds showed morpholino (
3f
) and imidazolyl (
3g
) derivatives as promising anticonvulsant lead. Furthermore,
In silico
drug-likeness parameters have also been investigated for filtering out the likelihood of poor drug absorption or brain penetration. 3D four-point pharmacophore measurements of compounds were also carried out to match these with established anticonvulsants agents.