Abstract
Simple synthetic strategies for the hitherto unreported [1,2,4]triazolo[4,3-
a]pyrido[4,3-
d]pyrimidines
8 and [1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-
b][1,6]naphthyridine-5-one
15 are described based on reaction of thione
3 and
12 with hydrazonoyl chloride
1a–
h, respectively. The structures of products
8 and
15 were confirmed by spectroscopic and X-ray crystallographic analyses. Also, the mechanism of such reactions was discussed. In addition, reaction of compound
12 with bromoacetic acid and hydrazine hydrate was investigated. Compounds were screened against 5α-reductase and showed activities with good LD
50 and LD
90 for all compounds.
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