Abstract
A series of bis-Schiff bases of isatin
1–
27 has been synthesized and screened for their antiglycation activity in vitro.
Where R
1, R
2, and R
3 are mono- and disubstituted chloro analogs while R
4 may be substituted aryl groups.
Bis-Schiff bases
1–
27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds
21 (IC
50
=
243.95
±
4.59
μM),
20 (IC
50
=
257.61
±
5.63
μM), and
7 (IC
50
=
291.14
±
2.53
μM) showed an excellent antiglycation activity better than the standard (rutin, IC
50
=
294.46
±
1.50
μM). This study has identified a series of potential molecules as antiglycation agents. A structure–activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.