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Synthesis of bis-diosgenin pyrazine dimers: New cephalostatin analogs
Journal article   Peer reviewed

Synthesis of bis-diosgenin pyrazine dimers: New cephalostatin analogs

Khaled Q. Shawakfeh, Naim H. Al-Said and Raed M. Ai-Zoubi
Steroids, Vol.73(6), pp.579-584
01/07/2008
DOI: https://doi.org/10.1016/j.steroids.2008.01.012
PMID: 18325555

Abstract

Biochemistry & Molecular Biology Endocrinology & Metabolism Life Sciences & Biomedicine Science & Technology
A convenient synthesis for bis-diosgenin pyrazine dimers, cephalostatin analogues is reported. These symmetrical dimeric steroid-pyrazines were obtained by the classical condensation of a-amino ketones, the most efficient method for pyrazine ring construction. (C) 2008 Elsevier Inc. All rights reserved.

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