Abstract
A series of linear tetrapeptides
and cyclooctapeptedopyridine derivatives
and
, were synthesized using
-dinicotinoyl-bis[(
-phenylalaninyl-
-leucyl)hydrazide]
as starting material. Acid hydrazide
was reacted with aromatic or heterocyclic aldehydes to give Schiff base derivatives
and
, respectively. Additionally, compound
was reacted with dicarboxylic acid anhydrides ortetracarboxylic diacid anhydrides to give the corresponding linear diimide carboxamides
, and octapeptide tetraimides
and
, respectively. The synthesized products were elucidated by using spectroscopic evidences and they were evaluated for their antibacterial activity by using streptomycin as reference antibiotic drug.