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Synthesis of chiral alpha-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines
Journal article   Peer reviewed

Synthesis of chiral alpha-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines

Ebrahim H. Ghazvini Zadeh, Bahaa El-Dien M. El-Gendy, Alex G. Pop and Alan R. Katritzky
MedChemComm, Vol.3(1), pp.52-55
01/01/2012
DOI: https://doi.org/10.1039/c1md00177a

Abstract

Biochemistry & Molecular Biology Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
Enantiopure N-(Cbz, Fmoc, Boc, or Ac)-1H-1,2,4-triazole- (8a-p, and 8f') and previously unknown N-Cbz-1,2,4-triazine-derived alpha-amino acids (11a-d, 11d', 13a,b, and 13a') were synthesized using microwave irradiation. Reaction conditions led unexpectedly to simultaneous cyclization, deprotection and acetylation of N-Boc-aminoacylamidrazones 7m,n to afford N-acetyl-1H-1,2,4-triazoles 8o,p.

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