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Synthesis of enantiomerically pure gamma-azidoalcohols by lipase-catalyzed transesterification
Journal article   Peer reviewed

Synthesis of enantiomerically pure gamma-azidoalcohols by lipase-catalyzed transesterification

Ahmed Kamal, M. Shaheer Malik, Ahmad Ali Shaik and Shaik Azeeza
Tetrahedron: asymmetry, Vol.19(9), pp.1078-1083
16/05/2008
DOI: https://doi.org/10.1016/j.tetasy.2008.03.028

Abstract

Chemistry Chemistry, Inorganic & Nuclear Chemistry, Organic Chemistry, Physical Physical Sciences Science & Technology
An enantioselective synthesis of chiral gamma-azidoalcohols via lipase-catalyzed resolution is described. The efficiency of various lipases and the effect of different solvents have been studied. Pseudomonas cepacia immobilized on diatomaceous earth (PS-D) in n-hexane catalyzed the transesterification process in an efficient manner providing gamma-azidoalcohols in high enantiomeric excess. (C) 2008 Elsevier Ltd. All rights reserved.

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