Abstract
Graphic
An enantioselective synthesis of chiral β-azidoalcohols via the reduction of the corresponding ketoazides with NaBH
4 in the presence of moist aluminium oxide followed by an in situ lipase-mediated resolution is described. The efficiency of various lipases and the effect of solvents have also been studied for this method. The excellent results obtained under mild reaction conditions, indicates its applicability and importance over classical methods previously reported.