Abstract
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•Exfoliated bentonite/cellulose composite was used as carrier for Oxaliplatin drug.•It is of 587 mg/g as maximum experimental loading capacity for the drug molecules.•The equilibrium studies verified physisorption loading mechanism in monolayer form.•The release profile continued for 100 h without complete diffusion for the drug.•It is of 94.3% and 23% cell viability for CCD-18Co and HCT116, respectively.
Exfoliated bentonite/cellulose nanocomposite was synthesized as a carrier for Oxaliplatin drug. The composite is of 587.4 mg g−1 loading capacity and the loading mechanism fitted with Pseudo-first order kinetic and Langmuir isotherm models. The composite shows continuous and slow release profile for 100 h with 83.3% (pH 5.5) and 93.4% (pH 7.4) as maximum releasing percentages. The diffusion exponents from the kinetic models (0.58 (pH 7.4) and 0.79 (pH 5.5)) suggested erosion and diffusion release mechanisms. The composite is of 94.3% cell viability for the normal cells and 23% for the colorectal cancer cells.