Abstract
Over the last few years, nanomedicine has gained prominence as a technology that can improve human health. Nanomedicine uses nanoscale materials to detect, treat, and prevent diseases. In this investigation, we synthe-sized g-C3N4/silver sulfide nanohybrids using a low-cost, rapid, simple, and environmentally friendly method. The morphological properties of g-C3N4/Ag2S were examined using a scanning electron microscope (SEM) and transmission electron microscope (TEM). A TEM image of the g-C3N4/Ag2S hybrid shows spherical silver sulfide nanostructures conjugated to g-C3N4 with a diameter between 30 and 65 nm. Dynamic light scattering (DLS) analysis determined that g-C3N4/Ag2S hybrid have an average particle size distribution of 141 nm. In addition, we have modified g-C3N4/Ag2S hybrid with folic acid (FA) for the photothermal treatment of breast cancer cells. The role of g-C3N4/Ag2S hybrid in cell viability and nuclear morphology of MCF-7 cells was investigated in the presence and absence of near-infrared (NIR) laser light irradiation at 808 nm. A high dose of Ag2S, FA/Ag2S, g-C3N4/Ag2S, and FA/g-C3N4/Ag2S caused 91 %, 80 %, 47 %, and 18 % of cell death, respectively. FA/g-C3N4/ Ag2S have biocompatibility than Ag2S, FA/Ag2S and g-C3N4/Ag2S. We observed high mortality rates when MCF-7 cells were irradiated with a NIR laser at 808 nm at a power density of 1000 mW with low dose FA/g-C3N4/ Ag2S. The results of this study suggest that FA/g-C3N4/Ag2S hybrid may be a valuable tool for fighting cancer.