Abstract
Green synthesized nanoparticles (NPs) have attracted enormous attention for their clinical and non-clinical applications. A natural polyphenol, gallo-tannin (GT) was used to reduce and cap the Fe
O
-NPs. GT-Fe
O
-NPs were synthesized following co-precipitation of FeCl
and FeSO
·7H
O with GT. Fe
O
-NPs absorbed light at 380 nm. Physicochemically, Fe
O
-NPs were spherical with slight aggregation and average diameter of 12.85 nm. X-ray diffraction confirmed crystallinity and EDX revealed the elemental percentage of iron and oxygen as 21.7% and 42.11%, respectively. FT-IR data confirmed the adsorption of gallo-tannin functional groups. Multiple drug-resistant (MDR)
(ESβL),
(ESβL), and
were found susceptible to 500-1000 μg GT-Fe
O
-NPs per ml. In synergy, Fe
O
-NPs enhanced the efficiency of some antibiotics. GT-Fe
O
NPs showed significant (
≤ 0.05) inhibition of growth and biofilm against MDR
,
, and
causing morphological and biofilm destruction. Violacein production (quorum sensing mediated) by
was inhibited by GT-Fe
O
-NPs in a concentration-dependent manner with a maximum decrease of 3.1-fold. A decrease of 11-fold and 2.32-fold in fungal mycelial growth and human breast cancer (MCF-7) cell viability, respectively was evident. This study suggests a plausible role of gallo-tannin capped Fe
O
-NPs as an alternative antibacterial, antiquorum sensing, antibiofilm, antifungal, and anti-proliferative agent.