Synthesis of new enantiomerically pure N-methyl-N-arylsulfonyl-alpha-aminonitriles from amino acids

Najeh Tka; Jamil Kraiem; Yakdhane Kacem; Amira Hajri; Bechir Ben Hassine

doi:10.1016/j.crci.2008.09.004

Back

Synthesis of new enantiomerically pure N-methyl-N-arylsulfonyl-alpha-aminonitriles from amino acids

Journal article

Peer reviewed

Synthesis of new enantiomerically pure N-methyl-N-arylsulfonyl-alpha-aminonitriles from amino acids

Najeh Tka, Jamil Kraiem, Yakdhane Kacem, Amira Hajri and Bechir Ben Hassine

Comptes rendus. Chimie, Vol.12(9), pp.1066-1071

01/09/2009

DOI: https://doi.org/10.1016/j.crci.2008.09.004

Abstract

Chemistry

Chemistry, Multidisciplinary

Physical Sciences

Science & Technology

New enantiomerically pure N-methyl-N-arylsulfonyl-alpha-aminonitriles were prepared starting from the corresponding alpha-amino acids by way of N-methyl-N-arylsulfonyt-alpha-amino amides. The key step of this sequence consists of the dehydration of amides by thionyl chloride which proceeded without a significant racemization. Enantiomeric purity of nitriles was determined by HPLC analysis. To cite this article: N. Tka et al., C R. Chimie 12 (2009). (C) 2008 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

Metrics

1 Record Views

Details

Title: Synthesis of new enantiomerically pure N-methyl-N-arylsulfonyl-alpha-aminonitriles from amino acids
Creators - without role: Najeh Tka - University of Monastir
Jamil Kraiem - University of Monastir
Yakdhane Kacem - University of Monastir
Amira Hajri - University of Monastir
Bechir Ben Hassine - University of Monastir
Publication Details: Comptes rendus. Chimie, Vol.12(9), pp.1066-1071
Publisher: Elsevier
Number of pages: 6
Grant note: Ministry of Higher Education and Scientific research and Technology
Identifiers: 9933777608331
Academic Unit: University of Tabuk
Language: English
Resource Type: Journal article