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Synthesis of new polysubstituted (pyrazoles, pyrimidines and quinolines) five and six-membered heterocycles: reaction of alpha,alpha-dioxoketene dithioacetals with nucleophiles
Journal article   Peer reviewed

Synthesis of new polysubstituted (pyrazoles, pyrimidines and quinolines) five and six-membered heterocycles: reaction of alpha,alpha-dioxoketene dithioacetals with nucleophiles

M. A. Ebraheem, K. M. Lokanatha Rai, N. U. Kudva N and A. S. Bahjat
Tetrahedron letters, Vol.51(27), pp.3486-3492
07/07/2010
DOI: https://doi.org/10.1016/j.tetlet.2010.04.003

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A novel synthesis of polysubstituted pyrazoles 3a-d, pyrimidines 4a-f and quinolines 5a-c via the reaction of alpha,alpha-oxoketene dithioacetals 2a-c with hydrazine hydrate, malonohydrazide, urea, thiourea and aniline is reported and the synthetic potential of the method is demonstrated. The structure of the new compounds was established upon their elemental analysis, IR, H-1 NMR and C-13 NMR. (C) 2010 Elsevier Ltd. All rights reserved.

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