Synthesis of new pyrazolo[4,3- e]-1,2,4-triazolo[1,5- c]pyrimidines and related heterocycles

Pier Giovanni Baraldi; Hussein El-Kashef; Abdel-Rahman Farghaly; Patrice Vanelle; Francesca Fruttarolo

doi:10.1016/j.tet.2004.04.010

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Synthesis of new pyrazolo[4,3- e]-1,2,4-triazolo[1,5- c]pyrimidines and related heterocycles

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Synthesis of new pyrazolo[4,3- e]-1,2,4-triazolo[1,5- c]pyrimidines and related heterocycles

Pier Giovanni Baraldi, Hussein El-Kashef, Abdel-Rahman Farghaly, Patrice Vanelle and Francesca Fruttarolo

Tetrahedron, Vol.60(23), pp.5093-5104

31/05/2004

DOI: https://doi.org/10.1016/j.tet.2004.04.010

Abstract

5-Amino-4-imino-1-substituted-1 H-pyrazolo[3,4- d]pyrimidines

Adenosine antagonists

Pyrazolo[4,3- e]-1,2,4-triazolo[1,5- c]pyrimidines

Reactivity studies

The reaction between 5-amino-4-imino-1(2)-substituted-1(2) H-4,5-dihydropyrazolo[3,4- d]pyrimidines and several commercially available reactants afforded new heterocycles with a conserved pyrazolo[3,4- d]pyrimidine nucleus. The key intermediates employed proved to be suitable compounds by virtue of their two vicinal amino and imino groups that were used to obtain five, six and seven-membered rings. Graphic

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Title: Synthesis of new pyrazolo[4,3- e]-1,2,4-triazolo[1,5- c]pyrimidines and related heterocycles
Creators - without role: Pier Giovanni Baraldi - University of Ferrara
Hussein El-Kashef - Assiut University
Abdel-Rahman Farghaly - Assiut University
Patrice Vanelle - Laboratoire de Chimie Organique
Francesca Fruttarolo - University of Ferrara
Publication Details: Tetrahedron, Vol.60(23), pp.5093-5104
Publisher: Elsevier Ltd
Identifiers: 9917835908331
Academic Unit: Jazan University
Language: English
Resource Type: Journal article