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Synthesis of new salicylamide derivatives with evaluation of their antiinflammatory, analgesic and antipyretic activities
Journal article   Peer reviewed

Synthesis of new salicylamide derivatives with evaluation of their antiinflammatory, analgesic and antipyretic activities

H H Fahmy and G A Soliman
Archives of pharmacal research, Vol.24(3), pp.180-189
01/06/2001
PMID: 11440073

Abstract

A new series of pyridazine, pyrazoles, pyrazolidine-3,5-dione, Semicarbazide, thiosemicarbazides, hydantoin, thiohydantoins, 1,2,4-triazoles, S-triazolo[3,4-b]-1,3,4-thiadiazoles incorporated indirectly into salicylamide moiety at position 2 were synthesized. Also the synthesis of novel series of 3-salicylamido-2-hydroxypropyl-amine derivatives were prepared. Several of these compounds were screened for antiinflammatory, analgesic, antipyretic and ulcerogenic activities.

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