Abstract
A series of new pyrimidine derivatives were synthesized, including sulfapyrimidines and pyrazolo[1,5-a]pyrimidines. In basic medium, pyrimidine compounds were produced by reacting sulfa guanidine with either 2-cyano-3-(dimethylamino)-N-acrylamides or N-(4-chlorophenyl)-2-cyano-3-(4-aryl)-acrylamides. The reaction of 5-amino-1H-pyrazole-4-carboxamides with either 2-cyano-3-(dimethylamino)-N-acrylamides or N-(4-chlorophenyl)-2-cyano-3-(4-aryl)acrylamides resulted in the synthesis of pyrazolo[1,5-a]pyrimidine compounds.