Abstract
A new series of ethoxymethyleneimino sulfa drug (2a-d), alpha-tocopheryl acetamide (5), (N-substituted)sulfamoyl)phenylimino)methyl)alpha-tocopheryl acetamide (6a-d), and (N-substituted)sulfamoyl)phenyl)alpha-tocopheryl acetamide (9a-d) derivatives were synthesized. The newly synthesized compounds were confirmed by spectroscopic tools (IR, H-1 NMR, and C-13 NMR, and mass spectra) and evaluated for their antibacterial activities against Gram-positive and Gram-negative bacteria. Gram-negative bacteria, Pseudomonas aeruginosa and Salmonella sp. and Enterococcus italicus showed resistance to all the standard compounds. The compounds 5, 6a, and 9d were the most potent antibacterial compounds on methicillin-resistant Staphylococcus aureus with MIC range from 0.1 to 0.3mg/mL and MBC range from 0.2 to 0.4mg /mL, respectively. The combination between sulfa drugs and vitamin E has proved to be effective antimicrobial activity against the Gram-negative for the first time in addition to Gram-positive bacteria.
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