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Synthesis of phenanthridine and its analogues via aerobic ligand-free domino Suzuki coupling-Michael addition reaction catalyzed by in situ generated palladium-nanoparticles in water
Journal article   Peer reviewed

Synthesis of phenanthridine and its analogues via aerobic ligand-free domino Suzuki coupling-Michael addition reaction catalyzed by in situ generated palladium-nanoparticles in water

Munmun Ghosh, Atiur Ahmed, Shubhendu Dhara and Jayanta K. Ray
Tetrahedron letters, Vol.54(36), pp.4837-4840
04/09/2013
DOI: https://doi.org/10.1016/j.tetlet.2013.06.089

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A convenient methodology has been developed towards the synthesis of substituted phenanthridines and analogous benzo[k] and benzo[i] derivatives via aerobic ligand-free domino Suzuki coupling-Michael addition reaction in the presence of Pd(OAc)(2) and K3PO4 as a catalytic system in H2O at 90 degrees C in good yields. Reaction was believed to be catalyzed by in situ generated palladium nanoparticles in water with the elimination of acetone. (C) 2013 Elsevier Ltd. All rights reserved.

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