Abstract
Phenyl thiazole hydrazone derivatives
1
–
21
have been synthesized and screened for their in vitro antiglycation activity. Hydrazones
1
–
21
displayed assorted antiglycation activities having IC
50
values in the range of 187.61 ± 1.12–886.98 ± 5.29 µM as compared to standard rutin (IC
50
= 269.07 ± 3.79 µM). Compounds
5
(IC
50
= 187.61 ± 1.12 µM),
3
(IC
50
= 191.92 ± 3.08 µM),
4
(IC
50
= 193.77 ± 3.06 µM),
6
(IC
50
= 217.90 ± 2.48 µM),
15
(IC
50
= 221.98 ± 2.34 µM),
2
(IC
50
= 226.59 ± 1.19 µM),
21
(IC
50
= 229.67 ± 1.95 µM),
18
(IC
50
= 231.09 ± 0.38 µM),
12
(IC
50
= 242.94 ± 2.05 µM), and
1
(IC
50
= 264.22 ± 5.60 µM), respectively, showed excellent antiglycation activities superior to standard rutin. Compound
17
(IC
50
= 269.94 ± 1.11 µM) demonstrated a comparable activity to the standard. Compounds
7
,
8
,
9
,
10
,
11
,
13
,
14
, and
16
exhibited weaker activities than standard. However, compounds
19
and
20
showed no activity. When evaluated for cytotoxicity against rat fibroblast cell line (3T3 cell line), all compounds were found to be non-toxic in cellular model.