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Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents
Journal article   Peer reviewed

Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents

Mohammed B. Alshammari, Mohamed Ramadan, Ashraf A. Aly, Essmat M. El-Sheref, Md Afroz Bakht, Mahmoud A. . A. . Ibrahim and Ahmed M. Shawky
Journal of molecular structure, Vol.1230, pp.129649-129649
15/04/2021
DOI: https://doi.org/10.1016/j.molstruc.2020.129649
PMID: 33223566

Abstract

Chemistry Chemistry, Physical Physical Sciences Science & Technology
We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M-pro) comparable to Remdesivir. (C) 2020 Elsevier B.V. All rights reserved.

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