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Synthesis of primary amines via nucleophilic addition of organometallic reagents to aldimines on solid support
Journal article   Peer reviewed

Synthesis of primary amines via nucleophilic addition of organometallic reagents to aldimines on solid support

A R Katritzky, L H Xie, G F Zhang, M Griffith, K Watson and J S Kiely
Tetrahedron letters, Vol.38(40), pp.7011-7014
06/10/1997
DOI: https://doi.org/10.1016/S0040-4039(97)01639-0

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Resin-immobilized aldimines 5, derived from the condensation of amine-functionalized Rink polystyrene resin with aldehydes, react with Grignard reagents, lithium reagents or LiBH4 to afford a wide variety of primary amines in good to excellent yields upon trifluoroacetic acid cleavage. In this amine synthesis, Rink resin functions both as a solid support and as a NH protecting group. (C) 1997 Elsevier Science Ltd.

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