Abstract
A series of 2-(omega-substituted acetamido)-4,5-trimethylene thiophene 4a-c have been synthesized by replacing omega-chloro of 3 by various nucleophiles. Schiffs bases and 2-acetyl derivatives of 2-amino-3-(N-p-tolyl carboxamido)-4,5-trimethylene thiophene 1 were also synthesized. The synthesized compounds have been characterized on the basis of elemental analysis and spectral studies and screened for their analgesic and antiinflammatory activities. Some of the compounds exhibit significant activities.