Abstract
A series of triazolo-thiadiazole derivatives have been synthesized from 2-naphthoxyacetic acid and evaluated for their anti-inflammatory and analgesic activity. Compounds which show good anti-inflammatory activity in comparision to standard drug naproxen have been further evaluated for their ulcerogenic and lipid peroxidation activity. The compounds 6(2-chlorophenyl)-3-[(naphthalen-2-yloxy)methyl]-[1,2,4]triazolo[3,4-b] [1,3,4] thiadiazole 3b and 6 - (2,4-dichlorophenyl)3-[(naphthalene -2-yloxy)methy1]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 3c show maximum anti-inflammatory activity with reduced ulcerogenic potential and have also been evaluated for their hepatotoxicity and histopathological characteristics.