Abstract
3-Methylpyrazolin-5-ones (1a,b) reacted with cycloalkanones (2a-d) in the presence of fused sodium acetate gave the corresponding 3-methyl-4-cycloalkylidene-pyrazolin-5-ones (3a-h). Reaction of compounds 3a-h with hydrazine hydrate, phenyl hydrazine, hydroxylamine hydrochloride, urea and thiourea afforded the corresponding spiropyrazolopyrazoles (4a-p), spiropyrazoloisoxazoles (5a-h) and spiropyrazolopyrimidinones and spiropyrazolothiopyrimidinones (6a-p) repectively. All the synthesized spiropyrazoloheterocyclic derivatives were identified by conventional methods (IR,H-1 NMR) and elemental analyses.