Abstract
2,3-Dimethyl-3H-quinazoline derivatives 2a,b reacted with malonic acid in the presence of anhydrous ZnCl2 to afford 1-[4-quinazolinylidene] acetic acid derivatives 3a,b which then reacted with thionyl chloride to give the corresponding acid chlorides. The acid chlorides reacted with arenes in the presence of AlCl3 to yield substituted 4-quinazolinylideneacetophenones 4a-d. Compounds 4a-d were treated with hydrazine derivatives, hydroxylamine hydrochloride, urea and thiourea to yield the spiro compounds 5a-h, 6a-d and 7a-h, respectively.