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Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening
Journal article   Open access  Peer reviewed

Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening

Ahmed M. Alafeefy, Adel S. El-Azab, Menshawy A. Mohamed, Mohamed Afroz Bakhat and S.G. Abdel-Hamid
Journal of Saudi Chemical Society, Vol.15(4), pp.319-325
10/2011
DOI: https://doi.org/10.1016/j.jscs.2011.07.005

Abstract

6-Iodo-2-thienylquinazolin-4(3H)-one Antimicrobial screening Synthesis
A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles, 1,2,4-triazino[3,4-c]quinazoline, benzimidazo[1,2-c]quinazoline and quinazoline-bearing thiazolidinone moiety proved to contribute for antimicrobial activity. The detailed synthesis and their antimicrobial screening are reported.
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https://doi.org/10.1016/j.jscs.2011.07.005View
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