Abstract
A new series of 1,3,4-thiadiazole derivatives was synthesized and the structures of these compounds were established by means of IR, H-1-NMR and elemental analysis. The compounds AR-5, AR-6, AR-7, AR-8 and AR-14 were screened for anticonvulsant activity on albino mice. Most of these compounds showed promising anticonvulsant activity. Structural modification of these compounds may lead to the discovery of more potent anticonvulsant agents with lower neurotoxicity.