Synthesis of some novel phenylfuro[3,2-d]pyrimidine glycosides derivatives with expected antimicrobial activity

Amira A. Ghoneim; Ahmed F. El-Farargy; Nadia A. A. Elkanzi

doi:10.1007/s13738-019-01768-2

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Synthesis of some novel phenylfuro[3,2-d]pyrimidine glycosides derivatives with expected antimicrobial activity

Journal article

Peer reviewed

Synthesis of some novel phenylfuro[3,2-d]pyrimidine glycosides derivatives with expected antimicrobial activity

Amira A. Ghoneim, Ahmed F. El-Farargy and Nadia A. A. Elkanzi

Journal of the Iranian Chemical Society, Vol.17(2), pp.319-325

01/02/2020

DOI: https://doi.org/10.1007/s13738-019-01768-2

Abstract

Analytical Chemistry

Biochemistry

Chemistry

Chemistry and Materials Science

general

Inorganic Chemistry

Organic Chemistry

Original Paper

Physical Chemistry

Reaction of ethyl 3-amino-5-phenylfuran-2-carboxylate 1 with benzoyl isothiocyanate gave 2,3-dihydro-6-phenyl-2-thioxofuro[3,2- d ]pyrimidin-4-one. Compound 3 was reacted with benzyl chloride to afford 2-(benzylthio)-6-phenylfuro[3,2- d ]pyrimidin-4-one 4 and also reacted with bromoglucopyranosyl to give S -glycoside 5 . The cyclization of ethyl 3-amino-5-phenylfuran-2-carboxylate 1 using thiourea, aniline, and carbon disulfide gave phenylfuro[3,2- d ]pyrimidine derivatives. The pharmacological properties for the synthesized compounds were reported.

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Title: Synthesis of some novel phenylfuro[3,2-d]pyrimidine glycosides derivatives with expected antimicrobial activity
Creators - without role: Amira A. Ghoneim - Zagazig University
Ahmed F. El-Farargy - Zagazig University
Nadia A. A. Elkanzi - Al Jouf University
Publication Details: Journal of the Iranian Chemical Society, Vol.17(2), pp.319-325
Publisher: Springer Berlin Heidelberg
Identifiers: 9913150908331
Academic Unit: Taif University
Language: English
Resource Type: Journal article