Synthesis of some pyridine, thiopyrimidine, and isoxazoline derivatives based on the pyrrole moiety

Mohamed A. A. Radwan; Eman M. H. Abbas

doi:10.1007/s00706-008-0061-y

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Synthesis of some pyridine, thiopyrimidine, and isoxazoline derivatives based on the pyrrole moiety

Journal article

Peer reviewed

Synthesis of some pyridine, thiopyrimidine, and isoxazoline derivatives based on the pyrrole moiety

Mohamed A. A. Radwan and Eman M. H. Abbas

Monatshefte für Chemie, Vol.140(2), pp.229-233

01/02/2009

DOI: https://doi.org/10.1007/s00706-008-0061-y

Abstract

Analytical Chemistry

Chemistry

Chemistry and Materials Science

Chemistry/Food Science

general

Inorganic Chemistry

Organic Chemistry

Original Paper

Physical Chemistry

Theoretical and Computational Chemistry

Condensation of 2-acetylpyrrole with 5-methylfuran-2-carboxyaldehyde and 4-chlorobenzaldehyde in 20% NaOH give the corresponding 2-chalconylpyrroles. Some new 2-alkoxy-3-cyano-4,6-diarylpyridines were synthesized by condensation of chalcones with malononitrile, followed by cyclization in sodium alkoxide. The reactivity of chalcones towards nitrogen nucleophiles such as thiourea and hydroxylamine hydrochloride to provide thiopyrimidine s and isoxazolines was investigated. Graphical Abstract

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Title: Synthesis of some pyridine, thiopyrimidine, and isoxazoline derivatives based on the pyrrole moiety
Creators - without role: Mohamed A. A. Radwan - Applied Organic Chemistry Department, National Research Centre
Eman M. H. Abbas - National Research Centre
Publication Details: Monatshefte für Chemie, Vol.140(2), pp.229-233
Publisher: Springer Vienna
Identifiers: 9928752408331
Academic Unit: Qassim University
Language: English
Resource Type: Journal article