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Synthesis of triazole-linked morpholino oligonucleotides via Cu-I catalysed cycloaddition
Journal article   Open access  Peer reviewed

Synthesis of triazole-linked morpholino oligonucleotides via Cu-I catalysed cycloaddition

Matthew J. Palframan, Rima D. Alharthy, Paulina K. Powalowska and Christopher J. Hayes
Organic & biomolecular chemistry, Vol.14(11), pp.3112-3119
01/01/2016
DOI: https://doi.org/10.1039/c6ob00007j
PMID: 26905296

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Triazole-linked morpholino ((MO)-M-TL) oligonucleic acids were synthesised using the Cu-I catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase synthesis. UV melting experiments showed that the (MO)-M-TL modification gives higher T-m values than the corresponding (TL)DNA modification.
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https://doi.org/10.1039/c6ob00007jView
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