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Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates
Journal article   Peer reviewed

Synthesis of trifluoromethylated acetylenes via copper-catalyzed trifluoromethylation of alkynyltrifluoroborates

Huidong Zheng, Yuanyuan Huang, Zhiwei Wang, Huaifeng Li, Kuo-Wei Huang, Yaofeng Yuan and Zhiqiang Weng
Tetrahedron letters, Vol.53(49), pp.6646-6649
05/12/2012
DOI: https://doi.org/10.1016/j.tetlet.2012.09.083

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A new method for the synthesis of trifluoromethylated acetylenes is developed which involves the copper-catalyzed trifluoromethylation of alkynyltrifluoroborates with an electrophilic trifluoromethylating reagent. This method offers significant advantages such as efficiency and mild and base-free reaction conditions. A plausible mechanism is proposed. (c) 2012 Published by Elsevier Ltd.

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