Abstract
A new series of enaminones 4a-e was prepared and their reaction with the hydrazonoyl chloride 2c gave 3,4'-bis(pyrazolyl) ketones 8a-d. Hydrazinolysis of 8 proved to be site selective as it yielded the respective 4-(pyrazol-3-yl)-2H-pyrazolo[3,4-d]pyridazines 9. The results of screening of the antitumor activity of enaminones 4a-e against human breast cell line MCF-7 revealed that all such compounds exhibited lower activity in relation to the reference drug Doxorubicin and the activity of the enaminone having electron-accepting substituent is more than that having electron donating substituent.