Abstract
The paper emphasizes on the synthesis of Palladium(II) iodide complexes containing based ligands. The new compounds of general formulae [Pd(L)(4)]I-2 where L = Thiourea (Tu), Methylthiourea (Metu), Dimethylthiourea (Dmtu), Tetramethylthiourea (Tmtu), Imidazolidine-2-thione (Imt), Mercaptopyridine (Mpy), Mercaptopyrimidine (Mpm), and Thionicotinamide (Tna) were prepared simply by reacting K-2[PdCl4] with the corresponding thioamides in 1:2 M ratio and then with 2 equivalents Potassium iodide. The complexes were characterized by elemental analysis and spectroscopic techniques (IR, H-1 and C-13 NMR). All the synthesized complexes were screened for antibacterial activity and some of compounds have shown good activities against both gram positive and gram negative bacteria. POM analyses reveal that the compounds are only slightly toxic and present a potential for antibacterial activity. Moreover, they have 16-23% drug score which is an important parameter for the compound possessing the drug properties. (C) 2015 The Authors. Alexandria University Faculty of Medicine. Production and hosting by Elsevier B.V.