Abstract
Herein, the present work comprises the synthesis of atorvastatin calcium (AVT) complexes with various transition metals. Ten kinds of complexes [Cr(AVT)
2
(Cl)(H
2
O)]·5H
2
O (
1
), [Mn(AVT)
2
(H
2
O)
2
] (
2
), [Fe(AVT)
2
(Cl)(H
2
O)]·9H
2
O (
3
), [Co(AVT)
2
(H
2
O)
2
]·8H
2
O (
4
), [Ni(AVT)
2
(H
2
O)
2
]·4H
2
O (
5
), [Cu(AVT)
2
(H
2
O)
2
] (
6
), [Zn(AVT)
2
]·2H
2
O (
7
), [Pt(AVT)
2
(Cl)
2
] (
8
), [Au(AVT)
3
] (
9
), and [Pd(AVT)(Cl)
2
] (
10
) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analyses. Results suggest that atorvastatin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against six different microorganisms, and the results were compared with the parent drug.