Abstract
Seven new platinum(II) complexes (1-7) of triethylphosphine (Et
P) and thiones (L) with general formula, cis-[Pt(Et
P)
(L)
]Cl
were prepared and characterized by elemental analysis, FTIR and NMR (
H,
C &
P) measurements. The analytical and spectroscopic data suggested the formation of the desired complexes. The complexes were tested for in vitro cytotoxicity against four cell lines: Hela (human cervical adenocarcinoma), MCF-7 (human breast carcinoma), A549 (human lung carcinoma), and HTC15 (human colon carcinoma). The anticancer activity values of compounds 1-6 are much better than cisplatin and carboplatin as indicated by their IC
values.