Abstract
This paper presents synthesis, characterization, computational and biological (anti-bacterial, antifugal, and anti-cancer) assessment studies of vital metal ions [Ca(II), Zn(II), Pt(II), Pd(II), and Au(III)] complexes of albendazole (Alb). Structures of the titled complexes cited herein were elucidated using elemental analysis, IR, Raman, H-1 and C-13 NMR, and electronic spectra. The results indicated formation of albendazole complexes by three fashions and albendazole reaction as a bidentate ligand bound to Ca(II), Zn(II), Pd(II), and Au(III) ions via the carbamide oxygen and/or benzimidazole nitrogen. Pt(II) ions coordinated with albendazole ligand via deprotonated benzimidazole ring. The molar conductance measurements confirmed non-electrolyte nature of 1 : 1 metal : ligand (Alb) complexes of Ca(II), Zn(II), and Au(II) and 1 : 2 complexes of Pt(II) and Pd(II). Thus, the complexes could be presented as [Ca-II(Alb)(0)(Cl)(2)(H2O)(2)], [Zn-II(Alb)(0)(Cl)(2)], [Pt-II(Alb)(2) (2-)(H2O)(2)], [Pd-II(Alb)(2) (2-)], and [Au-III(Alb)(-)(Cl)(2)]. Based on the Coats-Redfern and Horowitz-Metzeger methods the kinetic thermodynamic parameters of thermal decomposition have been deduced. The narrow size distribution in nanoscale range for the albendazole complexes is discussed using X-ray powder diffraction (XRD), scanning electron microscopy (SEM), X-ray energy dispersive spectrometery (EDX), and transmission electron microscopy (TEM). Computational studies data for the synthesized complexes are considered.