Abstract
New [Co(Mfn-HCl)(2)(NO3)(2)] center dot 6H(2)O complex has been synthesized and characterized using microanalytical, molar conductance, spectroscopic (IR and UV-Vis), effective magnetic moment, and thermal analyses. The infrared spectroscopic results data received from the comparison between free Mfn center dot HCl ligand and its cobalt(II) complex proved that Metformin forms complex with cobalt(II) ions as a bidentate ligand through its two imino groups. The antioxidant activity of the Mfn center dot HCl and Co(II)-2Mfn center dot HCl complex were evaluated by using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging method. Antitumor activity for Mfn center dot HCl ligand and its cobalt(II) complex was determined using Ehrlich Ascites carcinoma cell (EACC) line. It has been shown that the Co(II)-Mfn center dot HCl complex is much more effective as free radical scavenger and has higher antitumor activity than the free Mfn center dot HCl ligand.