Abstract
(HL) ligand is synthesized by treatment of ethene 1,2-diamine, 2-hydroxybenzaldehyde and furan-2-carbaldehyde in 1: 1:1 ratio. Co2+, Mn2+, Ni2+ and Zn2+ chelates have been designed and obtained. Thermal analysis, elemental analyses, conductivity and spectral measurements are factors but they are measurements or tools. The metal complexes were predicted to be not electrolytic due to their measured values of molar conductance. The arranged octahedral geometries of M(II) (Mn, Co, Ni and Zn) complexes are determined via magnetic moment and UV-Vis spectral data. Metal chelates' decomposition kinetics and thermal properties are observed using Coats-Redfern method. Entropy of activation (DS), activation energy (E) and pre-exponential factor (A), which are the kinetic parameters, were quantified. Molecular modeling assisted the optimization of metal complexes' geometry. Interaction of metal chelates with calf thymus DNA (CT-DNA) was evaluated via UV-Vis absorption and viscosity measurements. The obtained data elucidated that the complexes interact with DNA by partial or non-intercalative binding mode for these compounds. Also, the target compounds were tested for their in-vitro antimicrobial and anticancer efficacy. (C) 2020 Elsevier B.V. All rights reserved.